I feel blue.
= I'm blue./I have the blues.
憂鬱だ。

It's a no-win situation.
最悪だよ。

I'm disappointed.
へこむよ。

I'm depressed.
= I feel depressed./I'm feeling down.
落ち込んじゃって。

I feel miserable.
ボロボロだよ。

I feel empty.
むなしいな。

What makes you so grumpy?
= Why the long face?
何でそうご機嫌ななめなの?

Why so moody?
何でそう暗いわけ?

I've (completely) given up on it.
= I give up./Not a chance.
もうあきらめた。

There's no use in trying.
= We don't have a chance in hell.
やってもムダだ。

It doesn't matter any more.
= I don't care any more.
もうどうでもいいや。

I regret it.
= I regret what I've done./I'm sorry for what I did.
後悔してる。

It was a big mistake.
= What a mistake!
大きな間違いだったんだ。

I shouldn't have said that.
= I regret what I've said./I feel bad about what I've said.
あんなこと言わなきゃよかった。

Why did I do that?
= How on earth could I have done that?
何であんなことしちゃったんだろう?

I wish I could do it over again.
やり直せたらいいのに。

I can't get it off my mind.
= I can't get it out of my head.
そのことが頭から離れないんだ。
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I'm so sad.
悲しい。

I'm down in the dumps.
とても悲しいんだ。

Your story is making me sad.
それ聞いたら悲しくなってきた。

What's the matter with you?
いったいどうしちゃったんだよ?

I can't get over it.
= I can't seem to cheer up./I feel like I'll never be happy again.
立ち直れない。

I'm lonely.
= I feel alone.
寂しい。

I feel cut off.
ひとりぼっちだ。

I feel lost without you.
= I wish you were here./I miss you.
あなたがいなくて寂しい。
I'm in a big mess.
まずい。

This is serious!
ただごとではないよ!

It can't be!
= It can't be true!/Impossible!
あり得ない!

I'm in a pickle.
困ってるんだ。

The game is up.
もうダメだ。

It's over my head.
お手上げだ。

I'm at the end of my rope.
もう、あとがない。

I'm doomed.
もうおしまいだ。

You've done it now.
やっちゃったね。

It took me by surprise.
= I got caught with my pants down.
不意打ちを食らっちゃって。

I'm scared.
怖いよ。

That's creepy.
気味が悪いな。

I've got goose bumps.
= It gave me goose bumps.
鳥肌が立っちゃった。

I'm petrified.
= I'm scared stiff./I've got cold feet.
ぞっとする。

You gave me a fright.
= You startled me./You made me jump.
おどかさないでよ。

That's gross!
気持ち悪い!

I'm going to puke.
吐きそう。
My heart is beating so fast.
胸がドキドキする。

I'm getting nervous.
緊張してきた。

I can't relax.
= I have butterflies./I'm on pins and needles.
落ち着かないよ。

I feel flustered.
あせっちゃう。

I feel like running away.
逃げ出したい気分だ。

What am I supposed to do?
= I don't know what to do./What should I do?
どうすればいいんだろう?

I'm shy.
人見知りで。

I'm so embarrassed.
すごく恥ずかしい。

Shame on you!
= What a shame!
恥を知れよ!
It's driving me crazy.
腹が立つ。

You're driving me round the bend.
あなたには本当に頭にくる。

That's disgusting.
むかつくなあ。

I blew my top.
= I lost my temper.
もう限界だ。

How dare you!
よくもまあ!

How dare you say that!
よくもそんなことが言えるな。

Get lost!
あっちへ行け!
= Go away!/Get out of my sight!

Leave me alone.
= Stop bothering me.
ほっといてよ。

Give me a break.
やめてよ。

I'm in a bad mood.
= I'm irritated with (人)./I'm irritated at (物).
イライラする。

It's getting on my nerves.
イライラしてきた。

Don't fret.
= Don't let it get to you.
イラつかないで。

What's eating you?
何が気に入らないの?

Stop pestering me!
イライラさせないで!

The noise irritates me.
その音、イライラする。

What a hassle.
めんどうくさいなあ。

I'm not satisfied.
不満だね。
= This isn't good enough.

That doesn't explain it.
それじゃ納得できないね。
= It's not acceptable.
I'm really looking forward to it.
待ち遠しいなあ。

It's going to be great.
すごいことになるよ。

My heart is pounding.
ドキドキする。

Thank heavens!
ありがたい!

Whew!
やれやれ!

What a relief!
ああ、ほっとした!

I feel a lot better now.
よかった。

I'm relieved to hear that.
= I feel much better now that you've told me.
それを聞いて安心したよ。
I was (deeply) moved.
感動しちゃった。

It was great.
とてもよかった。

It touched me.
胸を打たれたよ。

I was impressed.
感心したよ。

You are a genius!
君って天才!

It will stay in my heart.
一生忘れない。

I respect you.
あなたを尊敬します。

It was a real eye-opener for me.
目を見張ったよ。
I did it!
やった!

I'm so pleased.
本当にうれしい。

I feel great!
いい気分!

It's (like) a dream come true.
夢みたいだ。

This is the happiest day of my life!
最高の日!

I'm super happy!
最高!

I couldn't be happier!
こんなに幸せなことはない!

It's too good to be true.
うそみたいだ。

It's my lucky day!
今日は、ついてる!

I'm walking on air.
うきうきする。

This is fun!
面白い!

I'm having a good time!
本当に楽しい!
= I'm really enjoying this!

What a laugh!
笑えるね!
= I can't stop laughing!

That's hilarious!
最高におかしい!

I wet myself.
笑いすぎた。
= I laughed until I cried.

I'm in a good mood today.
今日は機嫌がいいんだ。

I can't stop smiling.
うれしくてたまらない。
Let's drop the subject.
この話はこれまで。

That's about it.
これで終わり。

Why don't we stop talking?
話すのをやめませんか?

I don't want to talk any more.
もう、これ以上は話したくない。

I've heard enough about it.
もう、それ以上言わないで。

Enough already.
もうたくさん。
= That's enough./Enough is enough.

You've already told me.
もう聞いたよ。
= Somebody's already told me.
誰かから聞いた。

I'm sick of hearing it.
もうその話はうんざりよ。
Let's change the subject.
話題を変えよう。

Well, let's talk about something else.
さて、ほかの話をしようか。

Let's talk about something more fun.
もっと楽しい話をしようよ。

I don't want to talk about it.
その話はしたくないな。
= I'd prefer not to talk about it.

To change the subject, ...
話は変わるけどさ・・・。

That reminds me.
ああ、そうそう。

Now that you mention it, ...
そう言えばさ・・・。

Putting it aside, ...
それはさておき・・・。